Publications

2023

・Class VI G protein-coupled receptors in Aspergillus oryzae regulate sclerotia formation through GTPase-activating activity
Kim, D.M., Sakamoto, I., & Arioka, M.
Appl Microbiol Biotechnol, in press.

・Glucuronoyl esterase facilitates biomass degradation in Neurospora crassa by upregulating the expression of plant biomass-degrading enzymes
Wang, R. & Arioka, M.
J Gen Appl Microbiol. 2023 Mar 6;68(6):278-286

2022

・FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast
Mayuki Sasaki, Shinichi Nishimura, Yoko Yashiroda, Akihisa Matsuyama, Hideaki Kakeya, Minoru Yoshida.
iScience in press.

日本語解説はコチラ

・Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast.
Po-Chang Chiu, Yuri Nakamura, Shinichi Nishimura, Toshitsugu Tabuchi, Yoko Yashiroda, Go Hirai, Akihisa Matsuyama & Minoru Yoshida.
Scientific Reports 2022, 12, 17411.

日本語解説はコチラ

・Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium.
Ueoka, R., Sondermann, P., Leopold-Messer, S., Liu, Y., Suo, R., Bhushan, A., Vadakumchery, L., Greczmiel, U., Yashiroda, Y., Kimura, H., Nishimura, S., Hoshikawa, Y., Yoshida, M., Oxenius, A., Matsunaga, S., Williamson, R.T., Carreira, E.M. & Piel, J.
Nat Chem 2022, 14, 1193-1201.

・Differential Biosynthesis and Roles of Two Ferrichrome-Type Siderophores, ASP2397/AS2488053 and Ferricrocin, in Acremonium persicinum.
Asai, Y., Hiratsuka, T., Ueda, M., Kawamura, Y., Asamizu, S., Onaka, H., Arioka, M., Nishimura, S. & Yoshida, M.
ACS Chem. Biol. 2022, ;17, 207-216.

日本語解説はコチラ

2021

・Autophagy deficiency boosts the production of kojic acid in the filamentous fungus Aspergillus oryzae.
Chen, J. & Arioka, M.
Biosci. Biotechnol. Biochem. 2021, 85, 2429-2433.

・Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy for the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis.
Kanoh, N., Terajima, Y., Tanaka, S., Terashima, R., Nishiyama, H., Nagasawa, S., Sasano, Y., Iwabuchi, Y., Nishimura, S. & Kakeya, H.
J. Org. Chem. 2021, 86, 16231-16248

・Design, Synthesis, and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C.
Kanoh, N., Terashima, R., Nishiyama, H., Terajima, Y., Nagasawa, S., Sasano, Y., Iwabuchi, Y., Saito, H., Egoshi, S., Dodo, K., Sodeoka, M., Pan, C., Ikeuchi, Y., Nishimura, S. & Kakeya, H.
J. Org. Chem. 2021, 86, 16249-16258.

・Marine natural products targeting the eukaryotic cell membrane.
Nishimura, S.
J. Antibiot. 2021, 74, 769-785.

・Amphiol, an Antifungal Fungal Pigment from Pseudogymnoascus sp. PF1464.

Fujita, K., Ikuta, M., Nishimura, S.*, Sugiyama, R., Yoshimura, A. & Kakeya, H.*
J. Nat. Prod. 2021, 84, 986-992.

・Genomic and targeted approachs unveil the cell membrane as a major target of the antifungal cytotoxin amantelide A.

Elsadek, L.A., Matthews, J.H., Nishimura, S., Nakatani, T., Ito, A., Gu, T., Luo, D., Salvador-Reyes, L.A., Paul, V.J., Kakeya, H. & Luesch, H.*
ChemBioChem, 2021, 22, 1790-1799.

・Retro-aza-Michael reaction of an o-aminophenol adduct in protic solvents inspired by natural products.

Takenaka, K., Kaneko, K., Takahashi, N., Nishimura, S. & Kakeya, H.*
Bioorg. Med. Chem. 2021, 35, 116059.

・Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.

Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI* & Yoshida M.*
Nat. Chem. Biol. 2021, 17, 335-343.

・Functional analyses of xylanolytic enzymes involved in xylan degradation and utilization in Neurospora crassa.

Wang, R. & Arioka, M.*
Int. J. Biol. Macromol. 2021, 169, 302-310.

・天然物による細胞膜ステロールの分子認識と可視化への応用

西村慎一
細胞 2021, 53, 164-167.

2020

・A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.
Kobayashi H, Nishimura H, Kudo N, Osada H & Yoshida M.
Biosci. Biotechnol. Biochem. 2020, 84, 2113-2120.

・Genome-wide Survey of Ribosome Collision.

Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T & Iwasaki S.*
Cell Rep. 2020, 31, 107610.

・In vitro and in vivo characterization of genes involved in mannan degradation in Neurospora crassa.

Hsu, Y. & Arioka, M.*
Fungal Genet. Biol. 2020, 144, 103441.

・Biosynthesis of (R)-(-)-1-Octen-3-ol in Recombinant Saccharomyces cerevisiae with Lipoxygenase-1 and Hydroperoxide Lyase Genes from Tricholoma matsutake.

Lee, N.Y., Choi, D.H., Kim, M.G., Jeong, M.J., Kwon, H.J., Kim, D.H., Kim, Y.G., di Luccio, E., Arioka, M., Yoon, H.J.* & Kim, J.G.*
J. Microbiol. Biotechnol. 2020, 30, 296-305.

・Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast.

Kanou, A., Nishimura, S.*, Tabuchi, T., Matsuyama, A., Yoshida, M., Kato, T. & Kakeya, H.*
J. Antibiot. 2020, 73, 574–580.

・Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer.

Shirai, F.*, Mizutani, A., Yashiroda, Y., Tsumura, T., Kano, Y., Muramatsu, Y., Chikada, T., Yuki, H., Niwa, H., Sato, S., Washizuka, K., Koda, Y., Mazaki, Y., Jang, M.K. Yoshida, H., Nagamori, A., Okue, M., Watanabe, T., Kitamura, K., Shitara, E., Honma, T., Umehara, T., Shirouzu, M., Fukami, T., Seimiya, H., Yoshida, M. & Koyama, H.*
J. Med. Chem. 2020, 63, 4183-4204.

・Chemical diversity and mode of action of natural products targeting lipids in the eukaryotic cell membrane.

Nishimura, S.* & Matsumori, N.*
Nat. Prod. Rep. 2020, 37, 677-702.

・阻害剤によるヒストンアセチル化の調節.

高瀬翔平, 伊藤昭博 & 吉田稔.
医学のあゆみ 2020, 272, 115-122.

・Rolling-Circle Replication in Mitochondrial DNA Inheritance: Scientific Evidence and Significance from Yeast to Human Cells.

Feng, L. & Yoshida, M.
Genes 2020, 11, 514.

・血液脳関門透過性を有するヒストン脱アセチル化酵素阻害剤の探索.
住吉孝明、平中誠弥、出口芳春、伊藤昭博 & 吉田稔.

MEDCHEM NEWS 2020, 30, 43-46.

2019

・Distinct enzymatic and cellular characteristics of two phospholipases A1 in Aspergillus oryzae.

Nakagawara, C. & Arioka, M.*
Biochem. Biophys. Res. Commun. 2019, 518, 644-650.

・Isolation, Structure Elucidation, and Conformational Regulation of Myropeptins, Lipopeptides from the Fungus Myrothecium roridum.

Yoshimura, A., Nishimura, S.*, Suzuki, T., Hattori, A., Dohmae, N., Kato, T. & Kakeya, H.*
Org. Lett. 2019, 21, 7524-7528.

・Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1,2,3,4‐tetrahydroquinolines through Aggregate Formation.

Sugiyama, R., Nakatani, T., Nishimura, S.*, Takenaka, K., Ozaki, T., Asamizu, S., Onaka, H. & Kakeya, H.*
Angew. Chem. Int. Ed. 2019, 58, 13486-13491. [press release]

・Characterization of CBM36-containing GH11 endoxylanase NtSymX11 from the hindgut metagenome of higher termite Nasutitermes takasagoensis displaying prominent catalytic activity.

Kitamoto, M., Tokuda, G., Watanabe, H. & Arioka, M.
Carbohydr. Res. 2019, 474, 1-7.

・Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract.

Xiang, L.*, Wu, Q., Cheng, L., Sun, K., Li, J., Yoshida, M. & Qi, J.*
Oxid Med Cell Longev 2019, 2935315.

・Design, Synthesis and Structure-Activity Relationship Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.

Hiranaka, S., Arata, M., Nakata, A., Tanaka, A., Hashizume, Y., Kudo, N., Ito, A., Yoshida, M., Uesato, S., Nagaoka, Y. & Sumiyoshi, T.*
Heterocycles 2019, 101, 726-737.

・ビーチまで徒歩10秒．スクリプス海洋研究所で天然物化学を考える．

西村慎一．
MEDCHEM NEWS 2019, 29, 8-12. [PDF]

・Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines.

Ozaki, T., Sugiyama, R., Shimomura, M., Nishimura, S., Asamizu, S., Katsuyama, Y., Kakeya, H. & Onaka H.
Org. Biomol. Chem. 2019, 17, 2370-2378.

・Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol.

Cornelio, K., Espiritu, R.A., Hanashima, S., Todokoro, Y., Malabed, R., Kinoshita, M, Matsumori, N., Murata, M., Nishimura, S., Kakeya, H., Yoshida, M. & Matsunaga, S.
Biochim. Biophys. Acta 2019, 1861, 228-235.

・Recent advances in target identification of bioactive natural products.

Yoshida, M.
Biosci. Biotechnol. Biochem. 2019, 83, 1-9.

・Intraspecies cell-cell communication in yeast.

Yashiroda. Y. & Yoshida, M.
FEMS Yeast Research 2019, 19, foz071.

・Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement.

Radwan, M.O., Ciftci, H.I., Ali, T.F.S., Ellakwa, D.E., Koga, R., Tateishi, H., Nakata, A., Ito, A., Yoshida, M., Okamoto, Y., Fujita, M. & Otsuka, M.
Molecules 2019, 24, 3295.

・Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress.

Lin, Y., Kotakeyama, Y., Li, J., Pan, Y., Matsuura, A., Ohya, Y., Yoshida, M., Xiang, L. & Qi, J.
Oxid Med Cell Longev 2019, 4517091.

・Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure.

Takase, S., Kurokawa, R., Kondoh, Y., Honda, K., Suzuki, T., Kawahara, T., Ikeda, H., Dohmae, N., Osada, H., Shin-Ya, K., Kushiro, T., Yoshida, M. & Matsumoto, K.
ACS Chem Biol 2019, 14, 1819-1828.

・Identification of ryuvidine as a KDM5A inhibitor.

Mitsui, E., Yoshida, S., Shinoda, Y., Matsumori, Y., Tsujii, H., Tsuchida, M., Wada, S., Hasegawa, M., Ito, A., Mino, K., Onuki, T., Yoshida, M., Sasaki, R. & Mizukami, T.
Sci Rep 2019, 9, 9952.

・Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes.
Eda, S., Nasibullin, i, Vong, L., Kudo, N., Yoshida, M., Kurbangalieva, A. & Tanaka, K.
Nat. Catalysis 2019, 2, 780–792.

・Integrating yeast chemical genomics and mammalian cell pathway analysis.

Zhou, F, Li, S.C, Zhu, Y., Guo, W.J., Shao, L.J., Nelson, J., Simpkins, S., Yang, D.H., Liu, Q., Yashiroda, Y., Xu, J.B., Fan, Y.Y., Yue, J.N., Yoshida, M., Xia, T., Myers, C.L., Boone, C., Wang, M.W.
Acta Pharmacol Sin. 2019 40, 1245-1255.

・Glutamate Dehydrogenase from Thermus thermophilus Is Activated by AMP and Leucine as a Complex with Catalytically Inactive Adenine Phosphoribosyltransferase Homolog.

Tomita, T., Matsushita, H., Yoshida, A., Kosono, S., Yoshida, M., Kuzuyama, T. & Nishiyama, M.
J. Bacteriol. 2019, 201, e00710-18.

・Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1.

Ling, F., Bradshaw, E. & Yoshida, M.
Sci Rep. 2019, 9, 5433.

・Protein acetylation on 2-isopropylmalate synthase from Thermus thermophilus HB27.

Yoshida, A., Yoshida, M., Kuzuyama, T., Nishiyama, M. & Kosono, S.
Extremophiles 2019, 23, 377-388.

・New SIRT2 inhibitors: Histidine-based bleomycin spin-off.

Ali, T.F.S., Ciftci, H.I., Radwan, M.O., Koga, R., Ohsugi, T., Okiyama, Y., Honma, T., Nakata, A., Ito, A., Yoshida, M., Fujita, M. & Otsuka, M.
Bioorg Med Chem 2019, 27, 1767-1775.

・Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.

Shirai, F., Tsumura, T., Yashiroda, Y., Yuki, H., Niwa, H., Sato, S., Chikada, T., Koda, Y., Washizuka, K., Yoshimoto, N., Abe, M., Onuki, T., Mazaki, Y., Hirama, C., Fukami, T., Watanabe, H., Honma, T., Umehara, T., Shirouzu, M., Okue, M., Kano, Y., Watanabe, T., Kitamura, K., Shitara, E., Muramatsu, Y., Yoshida, H., Mizutani, A., Seimiya, H., Yoshida, M. & Koyama, H.
J Med Chem 2019, 62, 3407-3427.

・Dynamic changes in lysine acetylation and succinylation of the elongation factor Tu in Bacillus subtilis.

Suzuki, S., Kondo, N., Yoshida, M., Nishiyama, M. & Kosono, S.
Microbiology 2019, 165, 65-77.

2018

・A novel glucuronoyl esterase from Aspergillus fumigatus-the role of conserved Lys residue in the preference for 4-O-methyl glucuronoyl esters.

Huynh, H.H., Ishii, N., Matsuo, I. & Arioka, M.
Appl. Microbiol. Biotechnol. 2018, 102, 2191-2201.

・ヒストン脱アセチル化酵素が担う植物の環境ストレス応答制御 -植物をストレスに強くする標的タンパク質の発見-

上田実, 佐古香織, 伊藤昭博, 吉田稔 & 関原明.
化学と生物 2018, 56, 797-803.

・生体膜を標的にする天然有機化合物 -天然物による厳密な脂質認識とそれに基づく表現型-

西村慎一, 掛谷秀昭 & 松森信明.
化学と生物 2018, 56, 678-685.
（表紙に採用されました）

・Discovery of presaccharothriolide X, a retro-Michael reaction product of saccharothriolide B, from the rare actinomycete Saccharothrix sp. A1506.

Lu, S., Nishimura, S., Takenaka, K., Ito, M., Kato, T. & Kakeya, H.
Org. Lett. 2018, 20, 4406-4410 .

・Trp residue at subsite - 5 plays a critical role in the substrate binding of two protistan GH26 β-mannanases from a termite hindgut.

Hsu, Y., Koizumi, H., Otagiri, M., Moriya, S. & Arioka, M.
Appl. Microbiol. Biotechnol. 2018 102, 1737-1747.

・Along the Central Dogma-Controlling Gene Expression with Small Molecules.

Schneider-Poetsch, T. & Yoshida, M.
Annu Rev Biochem 2018, 87, 391-420.

・Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses.

Sohtome, Y., Shimazu, T., Barjau, J., Fujishiro, S., Akakabe, M., Terayama, N., Dodo, K., Ito, A., Yoshida, M., Shinkai, Y. & Sodeoka, M.
Chem Commun 2018, 54, 9202-9205.

・Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine.

Hirano, T., Fujiwara, T., Niwa, H., Hirano, M., Ohira, K., Okazaki, Y., Sato, S., Umehara, T., Maemoto, Y., Ito, A., Yoshida, M. & Kagechika, H.
ChemMedChem 2018, 13, 1530-1540.

・Proteome and acylome analyses of the functional interaction network between the carbazole-degradative plasmid pCAR1 and host Pseudomonas putida KT2440.

Vasileva, D., Suzuki-Minakuchi, C., Kosono, S., Yoshida, M., Okada, K. & Nojiri, H.
Environ Microbiol Rep 2018, 10, 299-309.

・Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.

Kudo, N., Ito, A., Arata, M., Nakata, A. & Yoshida, M.
Philos Trans R Soc Lond B Biol Sci 2018, 373, 20170070.

・Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria.

Nakamura, F., Kudo, N., Tomachi, Y., Nakata, A., Takemoto, M., Ito, A., Tabei, H., Arai, D., de Voogd, N., Yoshida, M., Nakao, Y. & Fusetani, N.
J. Antibiot. 2018, 71, 273-278.

・レプトマイシン物語　抗真菌抗生物質の探索から始まった新規がん分子標的治療への道.

吉田稔.
化学と生物 2018, 56, 197-202.

・生理活性物質の作用機序解明の技と未来.

吉田稔.
バイオサイエンスとインダストリー 2018, 76, 256-259.

2017

・Identification of zinc finger transcription factor EGR2 as a novel acetylated protein.

Noritsugu, K., Ito, A., Nakao, Y. & Yoshida, M.
Biochem Biophys Res Commun. 2017, 489, 455-459.

・Effect of lysine succinylation on the regulation of 2-oxoglutarate dehydrogenase inhibitor, OdhI, involved in glutamate production in Corynebacterium glutamicum.

Komine-Abe, A., Nagano-Shoji, M., Kubo, S., Kawasaki, H., Yoshida, M., Nishiyama, M. & Kosono, S.
Biosci Biotechnol Biochem. 2017, 81, 2130-2138.

・コータクチンのアセチル化によるがん細胞運動制御機構と創薬研究

伊藤昭博, 工藤紀雄 & 吉田 稔.
MEDCHEM NEWS 2017, 27, 190-194.